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Orbitofrontal Dopamine Depletion Upregulates Caudate Dopamine and Alters Behavior via Changes in Reinforcement Sensitivity

Schizophrenia is associated with upregulation of dopamine (DA) release in the caudate nucleus. The caudate has dense connections with the orbitofrontal cortex (OFC) via the frontostriatal loops, and both areas exhibit pathophysiological change in schizophrenia. Despite evidence that abnormalities in...

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書誌詳細
主要な著者: Clarke, H. F., Cardinal, R. N., Rygula, R., Hong, Y. T., Fryer, T. D., Sawiak, S. J., Ferrari, V., Cockcroft, G., Aigbirhio, F. I., Robbins, T. W., Roberts, A. C.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035526/
https://ncbi.nlm.nih.gov/pubmed/24872570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0718-14.2014
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