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Exosome Reduction In Vivo Is Associated with Lower Amyloid Plaque Load in the 5XFAD Mouse Model of Alzheimer’s Disease

We present evidence here that exosomes stimulate aggregation of Aβ1-42 in vitro and in vivo and interfere with uptake of Aβ by primary cultured astrocytes and microglia in vitro. Exosome secretion is prevented by inhibition of neutral sphingomyelinase 2 (nSMase2), a key regulatory enzyme generating...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Dinkins, Michael B., Dasgupta, Somsankar, Wang, Guanghu, Zhu, Gu, Bieberich, Erhard
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035236/
https://ncbi.nlm.nih.gov/pubmed/24650793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.02.012
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