Single-Cell Expression Profiling of Dopaminergic Neurons Combined with Association Analysis Identifies Pyridoxal Kinase as Parkinson’s Disease Gene

OBJECTIVE: The etiology of Parkinson disease (PD) is complex and multifactorial, with hereditary and environmental factors contributing. Monogenic forms have provided molecular clues to disease mechanisms but genetic modifiers of idiopathic PD are still to be determined. METHODS: We carried out whol...

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Hauptverfasser: Elstner, Matthias, Morris, Christopher M., Heim, Katharina, Lichtner, Peter, Bender, Andreas, Mehta, Divya, Schulte, Claudia, Sharma, Manu, Hudson, Gavin, Goldwurm, Stefano, Giovanetti, Alessandro, Zeviani, Massimo, Burn, David J., McKeith, Ian G., Perry, Robert H., Jaros, E., Krüger, Rejko, Wichmann, H.-Erich, Schreiber, Stefan, Campbell, Harry, Wilson, James F., Wright, Alan F., Dunlop, Malcolm, Pistis, Giorgio, Toniolo, Daniela, Chinnery, Patrick F., Gasser, Thomas, Klopstock, Thomas, Meitinger, Thomas, Prokisch, Holger, Turnbull, Douglass M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034432/
https://ncbi.nlm.nih.gov/pubmed/20035503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21780
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