Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions

BACKGROUND: Deletions of the mitochondrial DNA (mtDNA) accumulate to high levels in dopaminergic neurons of the substantia nigra pars compacta (SNc) in normal aging and in patients with Parkinson's disease (PD). Human nigral neurons characteristically contain the pigment neuromelanin (NM), whic...

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Detalhes bibliográficos
Main Authors: Elstner, Matthias, Müller, Sarina K, Leidolt, Lars, Laub, Christoph, Krieg, Lena, Schlaudraff, Falk, Liss, Birgit, Morris, Chris, Turnbull, Douglass M, Masliah, Eliezer, Prokisch, Holger, Klopstock, Thomas, Bender, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278372/
https://ncbi.nlm.nih.gov/pubmed/22188897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-4-43
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