Association of Cerebrospinal Fluid β-Amyloid 1-42, T-tau, P-tau(181), and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease

IMPORTANCE: We observed a significant correlation between cerebrospinal fluid (CSF) levels of tau proteins and α-synuclein, but not β-amyloid 1–42 (Aβ1–42), and lower concentration of CSF biomarkers, as compared with healthy controls, in a cohort of entirely untreated patients with Parkinson disease...

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Autores principales: Kang, Ju-Hee, Irwin, David J., Chen-Plotkin, Alice S., Siderowf, Andrew, Caspell, Chelsea, Coffey, Christopher S., Waligórska, Teresa, Taylor, Peggy, Pan, Sarah, Frasier, Mark, Marek, Kenneth, Kieburtz, Karl, Jennings, Danna, Simuni, Tanya, Tanner, Caroline M., Singleton, Andrew, Toga, Arthur W., Chowdhury, Sohini, Mollenhauer, Brit, Trojanowski, John Q., Shaw, Leslie M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034348/
https://ncbi.nlm.nih.gov/pubmed/23979011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2013.3861
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