NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

To subvert host immunity, influenza A virus (IAV) induces early apoptosis in innate immune cells by disrupting mitochondria membrane potential via its polymerase basic protein 1-frame 2 (PB1-F2) accessory protein. Whether immune cells have mechanisms to counteract PB1-F2–mediated apoptosis is curren...

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Autors principals: Jaworska, Joanna, Coulombe, François, Downey, Jeffrey, Tzelepis, Fanny, Shalaby, Karim, Tattoli, Ivan, Berube, Julie, Rousseau, Simon, Martin, James G., Girardin, Stephen E., McCullers, Jonathan A., Divangahi, Maziar
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034189/
https://ncbi.nlm.nih.gov/pubmed/24799673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322118111
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