Altered Matrix Metalloproteinase-2 and -9 Expression/Activity Links Placental Ischemia and Anti-angiogenic sFlt-1 to Uteroplacental and Vascular Remodeling and Collagen Deposition in Hypertensive Pregnancy

Preeclampsia is a complication of pregnancy manifested as maternal hypertension and often fetal growth restriction. Placental ischemia could be an initiating event, but the linking mechanisms leading to hypertension and growth restriction are unclear. We have shown an upregulation of matrix metallop...

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Autores principales: Li, Wei, Mata, Karina M., Mazzuca, Marc Q., Khalil, Raouf A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034157/
https://ncbi.nlm.nih.gov/pubmed/24704473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.03.017
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