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Cytoplasmic Dynein Moves Through Uncoordinated Stepping of the AAA+ Ring Domains

Cytoplasmic dynein is a homodimeric AAA+ motor that transports a multitude of cargos toward the microtubule minus end. How the two catalytic head domains interact and move relative to each other during processive movement is unclear. Here, we tracked the relative positions of both heads with nanomet...

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Autores principales: DeWitt, Mark A., Chang, Amy Y., Combs, Peter A., Yildiz, Ahmet
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033606/
https://ncbi.nlm.nih.gov/pubmed/22157083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1215804
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