Site-targeted non-viral gene delivery by direct DNA injection into the pancreatic parenchyma and subsequent in vivo electroporation in mice

The pancreas is considered an important gene therapy target because the organ is the site of several high burden diseases, including diabetes mellitus, cystic fibrosis, and pancreatic cancer. We aimed to develop an efficient in vivo gene delivery system using non-viral DNA. Direct intra-parenchymal...

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Bibliographic Details
Main Authors: Sato, Masahiro, Inada, Emi, Saitoh, Issei, Ohtsuka, Masato, Nakamura, Shingo, Sakurai, Takayuki, Watanabe, Satoshi
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2013
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033566/
https://ncbi.nlm.nih.gov/pubmed/23946268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/biot.201300169
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