Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension

BACKGROUND: Chloride intracellular channel 4 (CLIC4) is highly expressed in the endothelium of remodelled pulmonary vessels and plexiform lesions of patients with pulmonary arterial hypertension (PAH). CLIC4 regulates vasculogenesis through endothelial tube formation. Aberrant CLIC4 expression may c...

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Main Authors: Wojciak-Stothard, Beata, Abdul-Salam, Vahitha B., Lao, Ka Hou, Tsang, Hilda, Irwin, David C., Lisk, Christina, Loomis, Zoe, Stenmark, Kurt R., Edwards, John C, Yuspa, Stuart H., Howard, Luke S., Edwards, Robert J., Rhodes, Christopher J., Gibbs, J Simon R., Wharton, John, Zhao, Lan, Wilkins, Martin R.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033409/
https://ncbi.nlm.nih.gov/pubmed/24503951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.006797
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