Thrombospondin-1 Activation of Signal-Regulatory Protein-α Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury

Ischemia reperfusion injury (IRI) causes tissue and organ injury, in part, through alterations in tissue blood flow and the production of reactive oxygen species. The cell surface receptor signal-regulatory protein-α (SIRP-α) is expressed on inflammatory cells and suppresses phagocytosis, but the fu...

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Hlavní autoři: Yao, Mingyi, Rogers, Natasha M., Csányi, Gábor, Rodriguez, Andres I., Ross, Mark A., St. Croix, Claudette, Knupp, Heather, Novelli, Enrico M., Thomson, Angus W., Pagano, Patrick J., Isenberg, Jeffrey S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2014
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033366/
https://ncbi.nlm.nih.gov/pubmed/24511121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013040433
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