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IL-2–inducible T-cell kinase modulates T(H)2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4(+) T cells
BACKGROUND: Asthma is a predominantly T(H)2 cell–dominated inflammatory disease characterized by airway inflammation and a major public health concern affecting millions of persons. The Tec family tyrosine kinase IL-2–inducible T-cell kinase (Itk) is primarily expressed in T cells and critical for t...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033298/ https://ncbi.nlm.nih.gov/pubmed/23768572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.04.033 |
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