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IL-2–inducible T-cell kinase modulates T(H)2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4(+) T cells

BACKGROUND: Asthma is a predominantly T(H)2 cell–dominated inflammatory disease characterized by airway inflammation and a major public health concern affecting millions of persons. The Tec family tyrosine kinase IL-2–inducible T-cell kinase (Itk) is primarily expressed in T cells and critical for t...

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書誌詳細
主要な著者: Kannan, Arun K., Sahu, Nisebita, Mohanan, Sunish, Mohinta, Sonia, August, Avery
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033298/
https://ncbi.nlm.nih.gov/pubmed/23768572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.04.033
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