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Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA
RNA-guided endonucleases (RGENs) derived from the CRISPR/Cas system represent an efficient tool for genome editing. RGENs consist of two components: Cas9 protein and guide RNA. Plasmid-mediated delivery of these components into cells can result in uncontrolled integration of the plasmid sequence int...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cold Spring Harbor Laboratory Press
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4032848/ https://ncbi.nlm.nih.gov/pubmed/24696462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.171264.113 |
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