Selective Roles of E2Fs for ErbB2- and Myc-mediated Mammary Tumorigenesis

Previous studies have demonstrated that cyclin D1, an upstream regulator of the Rb/E2F pathway, is an essential component of the ErbB2/Ras (but not the Wnt/Myc) oncogenic pathway in the mammary epithelium. However, the role of specific E2fs for ErbB2/Ras-mediated mammary tumorigenesis remains unknow...

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Huvudupphovsmän: Wu, Lizhao, de Bruin, Alain, Wang, Hui, Simmons, Timothy, Cleghorn, Whitney, Goldenberg, Larry E., Sites, Emily, Sandy, April, Trimboli, Anthony, Fernandez, Soledad A., Eng, Charis, Shapiro, Charles, Leone, Gustavo
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032808/
https://ncbi.nlm.nih.gov/pubmed/24276244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.511
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