Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians

Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibr...

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Main Authors: Sgarbi, Gianluca, Matarrese, Paola, Pinti, Marcello, Lanzarini, Catia, Ascione, Barbara, Gibellini, Lara, Dika, Emi, Patrizi, Annalisa, Tommasino, Chiara, Capri, Miriam, Cossarizza, Andrea, Baracca, Alessandra, Lenaz, Giorgio, Solaini, Giancarlo, Franceschi, Claudio, Malorni, Walter, Salvioli, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032796/
https://ncbi.nlm.nih.gov/pubmed/24799450
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