WT1 maintains adrenal-gonadal-primordium (AGP) identity and marks a novel population of AGP-like progenitors within the adult adrenal gland

Adrenals and gonads share a common primordium (AGP), but the molecular events driving differentiation are poorly understood. Here we demonstrate that the Wilms’ tumor suppressor WT1 is a key factor defining AGP identity by inhibiting the steroidogenic differentiation process. Indeed, ectopic express...

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Bibliografski detalji
Glavni autori: Bandiera, Roberto, Vidal, Valerie P.I., Ranc, Fariba, Clarkson, Michael, Sahut-Barnola, Isabelle, von Gise, Alexander, Pu, William T., Hohenstein, Peter, Martinez, Antoine, Schedl, Andreas
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032791/
https://ncbi.nlm.nih.gov/pubmed/24135228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.09.003
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