The PDZ Domain of the Guanine Nucleotide Exchange Factor PDZGEF Directs Binding to Phosphatidic Acid during Brush Border Formation

PDZGEF is a guanine nucleotide exchange factor for the small G protein Rap. It was recently found that PDZGEF contributes to establishment of intestinal epithelial polarity downstream of the kinase Lkb1. By binding to phosphatidic acid enriched at the apical membrane, PDZGEF locally activates Rap2a...

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Bibliographic Details
Main Authors: Consonni, Sarah V., Brouwer, Patricia M., van Slobbe, Eleonora S., Bos, Johannes L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032295/
https://ncbi.nlm.nih.gov/pubmed/24858808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098253
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