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Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy

OBJECTIVE: A significant cause of spontaneous hemorrhages in the elderly is cerebral amyloid angiopathy (CAA), which causes degeneration of cerebral vessels, but the mechanisms are unclear. METHODS: We isolated leptomeningeal vessels from rapidly autopsied brains (the average of postmortem intervals...

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Autors principals: Cheng, Xin, He, Ping, Yao, Hailan, Dong, Qiang, Li, Rena, Shen, Yong
Format: Artigo
Idioma:Inglês
Publicat: Lippincott Williams & Wilkins 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032211/
https://ncbi.nlm.nih.gov/pubmed/24739782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000000403
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