Nalaganje...
MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability
Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair. Completion of HR in G1 cells can lead to the loss-of-heteroz...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
eLife Sciences Publications, Ltd
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4031983/ https://ncbi.nlm.nih.gov/pubmed/24843000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02445 |
| Oznake: |
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