MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability

Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair. Completion of HR in G1 cells can lead to the loss-of-heteroz...

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Detalhes bibliográficos
Main Authors: Choi, Young Eun, Pan, Yunfeng, Park, Eunmi, Konstantinopoulos, Panagiotis, De, Subhajyoti, D'Andrea, Alan, Chowdhury, Dipanjan
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031983/
https://ncbi.nlm.nih.gov/pubmed/24843000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02445
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