Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome

We investigated the hypotriglyceridemic mechanism of action of linalool, an aromatic monoterpene present in teas and fragrant herbs. Reporter gene and time-resolved fluorescence resonance energy transfer assays demonstrated that linalool is a direct ligand of PPARα. Linalool stimulation reduced cell...

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Autori principali: Jun, Hee-jin, Lee, Ji Hae, Kim, Jiyoung, Jia, Yaoyao, Kim, Kyoung Heon, Hwang, Kwang Yeon, Yun, Eun Ju, Do, Kyoung-Rok, Lee, Sung-Joon
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2014
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031941/
https://ncbi.nlm.nih.gov/pubmed/24752549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M045807
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