A COMPOSITE SCORING OF GENOTYPES DISCRIMINATES CORONARY HEART DISEASE RISK BEYOND CONVENTIONAL RISK FACTORS IN THE BOSTON PUERTO RICAN HEALTH STUDY

BACKGROUND AND AIMS: Using a genetic predisposition score (GPS), integrating the additive associations of a set of single nucleotide polymorphisms (SNPs) with CHD, we examined the consequences of the joint presence of a high GPS and conventional risk factors (CRFs). METHODS AND RESULTS: We studied e...

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Hlavní autoři: Junyent, Mireia, Tucker, Katherine L., Shen, Jian, Lee, Yu-Chi, Smith, Caren E., Mattei, Josiemer, Lai, Chao-Qiang, Parnell, Laurence D., Ordovas, Jose M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031647/
https://ncbi.nlm.nih.gov/pubmed/19501493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.numecd.2009.03.016
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