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An evolutionarily biased distribution of miRNA sites toward regulatory genes with high promoter-driven intrinsic transcriptional noise

BACKGROUND: miRNAs are a major class of regulators of gene expression in metazoans. By targeting cognate mRNAs, miRNAs are involved in regulating most, if not all, biological processes in different cell and tissue types. To better understand how this regulatory potential is allocated among different...

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Autori principali: Zare, Hossein, Khodursky, Arkady, Sartorelli, Vittorio
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031498/
https://ncbi.nlm.nih.gov/pubmed/24707827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2148-14-74
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