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Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial

BACKGROUND: No available treatments slow or halt progression of multiple system atrophy, which is a rare, progressive, fatal neurological disorder. In a mouse model of multiple system atrophy, rifampicin inhibited formation of α-synuclein fibrils, the neuropathological hallmark of the disease. We ai...

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Detalhes bibliográficos
Main Authors: Low, Phillip A, Robertson, David, Gilman, Sid, Kaufmann, Horacio, Singer, Wolfgang, Biaggioni, Italo, Freeman, Roy, Perlman, Susan, Hauser, Robert A, Cheshire, William, Lessig, Stephanie, Vernino, Steven, Mandrekar, Jay, Dupont, William D, Chelimsky, Thomas, Galpern, Wendy R
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030757/
https://ncbi.nlm.nih.gov/pubmed/24507091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(13)70301-6
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