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Decreased Mitochondrial SIRT3 Expression is Potential Molecular Biomarker Associated with Poor Outcome in Breast Cancer
SIRT3 is a genomically expressed, mitochondrial localized tumor suppressor protein where it directs multiple metabolic processes by deacetylating downstream protein substrates. Genetic deletion of Sirt3 in mice leads to the spontaneous development of mammary tumors starting at one year and decreased...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4030591/ https://ncbi.nlm.nih.gov/pubmed/24746213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2014.01.004 |
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