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Structure of the Predominant Protein Arginine Methyltransferase PRMT1 and Analysis of Its Binding to Substrate Peptides

PRMT1 is the predominant type I protein arginine methyltransferase in mammals and highly conserved among all eukaryotes. It is essential for early postim-plantation development in mouse. Here we describe the crystal structure of rat PRMT1 in complex with the reaction product AdoHcy and a 19 residue...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Xing, Cheng, Xiaodong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2003
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030380/
https://ncbi.nlm.nih.gov/pubmed/12737817
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