Combination Therapy With an Anti–IL-1β Antibody and GAD65 DNA Vaccine Can Reverse Recent-Onset Diabetes in the RIP-GP Mouse Model

Type 1 diabetes is thought to be an autoimmune condition in which self-reactive T cells attack insulin-secreting pancreatic β-cells. As a proinflammatory cytokine produced by β-cells or macrophages, interleukin-1β (IL-1β) represents a potential therapeutic target in diabetes. We reasoned IL-1β block...

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Autors principals: Pagni, Philippe P., Bresson, Damien, Rodriguez-Calvo, Teresa, Bel Hani, Amira, Manenkova, Yulia, Amirian, Natalie, Blaszczak, Alecia, Faton, Sina, Sachithanantham, Sowbarnika, von Herrath, Matthias G.
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2014
Matèries:
Immunology and Transplantation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030110/
https://ncbi.nlm.nih.gov/pubmed/24520125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-1257
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