Genetic-induced Variations in the GAD65 T-cell Repertoire Governs Efficacy of Anti-CD3/GAD65 Combination Therapy in New-onset Type 1 Diabetes

To enhance efficacy of forthcoming type 1 diabetes (T1D) clinical trials, combination therapies (CTs) are envisaged. In this study, we showed that efficacy of a CT, using anti-CD3 antibody and glutamic acid decarboxylase of 65 kd (GAD65)-expressing plasmid, to reverse new-onset T1D was dependent upo...

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Detalhes bibliográficos
Main Authors: Bresson, Damien, Fradkin, Matthew, Manenkova, Yulia, Rottembourg, Diane, von Herrath, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818225/
https://ncbi.nlm.nih.gov/pubmed/19690518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.197
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