Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice

Decreased heart rate variability (HRV) is a major risk factor for sudden death and cardiovascular disease. We previously demonstrated that parasympathetic dysfunction in the heart of the Akita type 1 diabetic mouse was due to a decrease in the level of the sterol response element–binding protein (SR...

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Autori principali: Zhang, Yali, Welzig, Charles M., Picard, Kristen L., Du, Chuang, Wang, Bo, Pan, Jen Q., Kyriakis, John M., Aronovitz, Mark J., Claycomb, William C., Blanton, Robert M., Park, Ho-Jin, Galper, Jonas B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2014
Soggetti:
Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030105/
https://ncbi.nlm.nih.gov/pubmed/24458356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1459
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