CONSTITUTIONAL METHYLATION OF THE BRCA1 PROMOTER IS SPECIFICALLY ASSOCIATED WITH BRCA1 MUTATION-ASSOCIATED PATHOLOGY IN EARLY-ONSET BREAST CANCER

Women carrying germline mutations in BRCA1 are at a substantially elevated risk of breast cancer and their tumors typically have distinctive morphological features. We hypothesised that constitutional methylation of the BRCA1 promoter region could give rise to such breast cancers in women. We select...

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Detalhes bibliográficos
Main Authors: Wong, Ee Ming, Southey, Melissa C, Fox, Stephen B, Brown, Melissa A, Dowty, James G, Jenkins, Mark A, Giles, Graham G, Hopper, John L, Dobrovic, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030007/
https://ncbi.nlm.nih.gov/pubmed/20978112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0212
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