A Modified Grapefruit Juice Eliminates Two Compound Classes as Major Mediators of the Grapefruit Juice-Fexofenadine Interaction: an In Vitro-In Vivo ‘Connect’

The grapefruit juice-fexofenadine interaction involves inhibition of intestinal organic anion transporting polypeptide (OATP)-mediated uptake. Only naringin has been shown clinically to inhibit intestinal OATP; other constituents have not been evaluated. The effects of a modified grapefruit juice de...

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Autors principals: Won, Christina S., Lan, Tian, VanderMolen, Karen M., Dawson, Paul A., Oberlies, Nicholas H., Widmer, Wilbur W., Scarlett, Yolanda V., Paine, Mary F.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029847/
https://ncbi.nlm.nih.gov/pubmed/23878024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.136
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