Mechanical Stretch Suppresses microRNA-145 Expression by Activating Extracellular Signal-Regulated Kinase 1/2 and Upregulating Angiotensin-Converting Enzyme to Alter Vascular Smooth Muscle Cell Phenotype

Phenotype modulation of vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis of various vascular diseases, including hypertension and atherosclerosis. Several microRNAs (miRNAs) were found involved in regulating the VSMC phenotype with platelet-derived growth factor (PDGF...

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Detalhes bibliográficos
Main Authors: Hu, Bo, Song, Jian tao, Qu, Hai yan, Bi, Chen long, Huang, Xiao zhen, Liu, Xin xin, Zhang, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029552/
https://ncbi.nlm.nih.gov/pubmed/24848371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096338
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