Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast cancer patients

BACKGROUND: Monoclonal antibodies (mAb), such as trastuzumab are a valuable addition to breast cancer therapy. Data obtained from neoadjuvant settings revealed that antibody-dependent cell-mediated cytotoxicity (ADCC) is a major mechanism of action for the mAb trastuzumab. Conflicting results still...

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Detalhes bibliográficos
Main Authors: Petricevic, Branka, Laengle, Johannes, Singer, Josef, Sachet, Monika, Fazekas, Judit, Steger, Guenther, Bartsch, Rupert, Jensen-Jarolim, Erika, Bergmann, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029549/
https://ncbi.nlm.nih.gov/pubmed/24330813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-307
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