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Denosumab for the treatment of bone metastases in breast cancer: evidence and opinion
Introduction: Denosumab, a fully human monoclonal antibody, targets the receptor activator of nuclear factor-kappaB (RANK) ligand, a protein essential for osteoclast differentiation, activity and survival. Loss of osteoclasts from the bone surface reduces bone turnover and bone loss in malignant and...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
SAGE Publications
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169928/ https://ncbi.nlm.nih.gov/pubmed/21957430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758834011412656 |
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