Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder

BACKGROUND: Aberrant biometal metabolism is a key feature of neurodegenerative disorders including Alzheimer’s and Parkinson’s diseases. Metal modulating compounds are promising therapeutics for neurodegeneration, but their mechanism of action remains poorly understood. Neuronal ceroid lipofuscinose...

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Detalhes bibliográficos
Principais autores: Grubman, Alexandra, Lidgerwood, Grace E, Duncan, Clare, Bica, Laura, Tan, Jiang-Li, Parker, Sarah J, Caragounis, Aphrodite, Meyerowitz, Jodi, Volitakis, Irene, Moujalled, Diane, Liddell, Jeffrey R, Hickey, James L, Horne, Malcolm, Longmuir, Shoshanah, Koistinaho, Jari, Donnelly, Paul S, Crouch, Peter J, Tammen, Imke, White, Anthony R, Kanninen, Katja M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029264/
https://ncbi.nlm.nih.gov/pubmed/24581221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-25
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