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Akt inhibitors: mechanism of action and implications for anticancer therapeutics

Akt, better known as protein kinase B (PKB), is a serine/threonine-specific protein kinase which acts as mediator via PI3K/Akt pathway in many biological processes like glucose metabolism, apoptosis, cell differentiation and transcription. Akt1 gene amplification has been implicated in gastric carci...

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מידע ביבליוגרפי
Main Authors: Bhutani, Jaikrit, Sheikh, Asfandyar, Niazi, Asfandyar Khan
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028840/
https://ncbi.nlm.nih.gov/pubmed/24330834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-9378-8-49
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