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Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells

How cellular metabolic activities regulate autophagy and determine the susceptibility to oxidative stress and ultimately cell death in neuronal cells is not well understood. An important example of oxidative stress is 4-hydroxynonenal (HNE), which is a lipid peroxidation product that is formed durin...

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Detalhes bibliográficos
Main Authors: Dodson, Matthew, Liang, Qiuli, Johnson, Michelle S, Redmann, Matthew, Fineberg, Naomi, Darley-Usmar, Victor M, Zhang, Jianhua
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028343/
https://ncbi.nlm.nih.gov/pubmed/24145463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.26094
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