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The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases

Redox and proteotoxic stress contributes to age-dependent accumulation of dysfunctional mitochondria and protein aggregates, and is associated with neurodegeneration. The free radical theory of aging inspired many studies using reactive species scavengers such as alpha-tocopherol, ascorbate and coen...

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Detalhes bibliográficos
Publicado no:Aging Dis
Main Authors: Redmann, Matthew, Darley-Usmar, Victor, Zhang, Jianhua
Formato: Artigo
Idioma:Inglês
Publicado em: JKL International LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809607/
https://ncbi.nlm.nih.gov/pubmed/27114848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2015.0820
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