MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age

To study mitochondrial protein age dynamics, we targeted a time-sensitive fluorescent protein, MitoTimer, to the mitochondrial matrix. Mitochondrial age was revealed by the integrated portions of young (green) and old (red) MitoTimer protein. Mitochondrial protein age was dependent on turnover rates...

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Autores principales: Ferree, Andrew W, Trudeau, Kyle, Zik, Eden, Benador, Ilan Y, Twig, Gilad, Gottlieb, Roberta A, Shirihai, Orian S
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028338/
https://ncbi.nlm.nih.gov/pubmed/24149000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.26503
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