A Novel MitoTimer Reporter Gene for Mitochondrial Content, Structure, Stress, and Damage in Vivo

Mitochondrial dysfunction plays important roles in many diseases, but there is no satisfactory method to assess mitochondrial health in vivo. Here, we engineered a MitoTimer reporter gene from the existing Timer reporter gene. MitoTimer encodes a mitochondria-targeted green fluorescent protein when...

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Detalhes bibliográficos
Main Authors: Laker, Rhianna C., Xu, Peng, Ryall, Karen A., Sujkowski, Alyson, Kenwood, Brandon M., Chain, Kristopher H., Zhang, Mei, Royal, Mary A., Hoehn, Kyle L., Driscoll, Monica, Adler, Paul N., Wessells, Robert J., Saucerman, Jeffrey J., Yan, Zhen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002107/
https://ncbi.nlm.nih.gov/pubmed/24644293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.530527
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