A Novel MitoTimer Reporter Gene for Mitochondrial Content, Structure, Stress, and Damage in Vivo

Mitochondrial dysfunction plays important roles in many diseases, but there is no satisfactory method to assess mitochondrial health in vivo. Here, we engineered a MitoTimer reporter gene from the existing Timer reporter gene. MitoTimer encodes a mitochondria-targeted green fluorescent protein when...

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Bibliographic Details
Main Authors: Laker, Rhianna C., Xu, Peng, Ryall, Karen A., Sujkowski, Alyson, Kenwood, Brandon M., Chain, Kristopher H., Zhang, Mei, Royal, Mary A., Hoehn, Kyle L., Driscoll, Monica, Adler, Paul N., Wessells, Robert J., Saucerman, Jeffrey J., Yan, Zhen
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4002107/
https://ncbi.nlm.nih.gov/pubmed/24644293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.530527
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