Probing Structure-Function Relationships in Missense Variants in the Carboxy-Terminal Region of BRCA1

Germline inactivating variants in BRCA1 lead to a significantly increased risk of breast and ovarian cancers in carriers. While the functional effect of many variants can be inferred from the DNA sequence, determining the effect of missense variants present a significant challenge. A series of bioch...

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Autors principals: Carvalho, Renato S., Abreu, Renata B. V., Velkova, Aneliya, Marsillac, Sylvia, Rodarte, Renato S., Suarez-Kurtz, Guilherme, Iversen, Edwin S., Monteiro, Alvaro N. A., Carvalho, Marcelo A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028255/
https://ncbi.nlm.nih.gov/pubmed/24845084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097766
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