Comprehensive Analysis of Missense Variations in the BRCT Domain of BRCA1 by Structural and Functional Assays

Genetic screening of the breast and ovarian cancer susceptibility gene BRCA1 has uncovered a large number of variants of uncertain clinical significance. Here, we use biochemical and cell-based transcriptional assays to assess the structural and functional defects associated with a large set of 117...

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Main Authors: Lee, Megan S., Green, Ruth, Marsillac, Sylvia M., Coquelle, Nicolas, Williams, R. Scott, Yeung, Telford, Foo, Desmond, Hau, D. Duong, Hui, Ben, Monteiro, Alvaro N.A., Glover, J.N. Mark
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3040717/
https://ncbi.nlm.nih.gov/pubmed/20516115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4563
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