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Delayed Administration of a Bio-Engineered Zinc-Finger VEGF-A Gene Therapy Is Neuroprotective and Attenuates Allodynia Following Traumatic Spinal Cord Injury

Following spinal cord injury (SCI) there are drastic changes that occur in the spinal microvasculature, including ischemia, hemorrhage, endothelial cell death and blood-spinal cord barrier disruption. Vascular endothelial growth factor-A (VEGF-A) is a pleiotropic factor recognized for its pro-angiog...

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Detalhes bibliográficos
Main Authors: Figley, Sarah A., Liu, Yang, Karadimas, Spyridon K., Satkunendrarajah, Kajana, Fettes, Peter, Spratt, S. Kaye, Lee, Gary, Ando, Dale, Surosky, Richard, Giedlin, Martin, Fehlings, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028194/
https://ncbi.nlm.nih.gov/pubmed/24846143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096137
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