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Estimation of Ligand Affinity Constants for Receptor States in Functional Studies Involving the Allosteric Modulation of G Protein-Coupled Receptors: Implications for Ligand Bias
INTRODUCTION: The affinity constants of a ligand for active and inactive states of a receptor ultimately determine its capacity to activate downstream signaling events. In this report, we describe a reverse-engineering strategy for estimating these microscopic constants. METHODS: Our approach involv...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028174/ https://ncbi.nlm.nih.gov/pubmed/24434717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vascn.2014.01.002 |
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