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Increasing both CoCrMo-alloy Particle Size and Surface Irregularity Induces Increased Macrophage Inflammasome Activation In vitro Potentially through Lysosomal Destabilization Mechanisms

Recent investigations indicate that innate immune “danger-signaling” pathways mediate metal implant debris induced-inflammatory responses, e.g. NALP3 inflammasome. How the physical characteristics of particles, (size, shape and chemical composition) affect this inflammatory reactivity remains contro...

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Main Authors: Caicedo, Marco S, Samelko, Lauryn, McAllister, Kyron, Jacobs, Joshua J, Hallab, Nadim J
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028039/
https://ncbi.nlm.nih.gov/pubmed/23794526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.22411
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