Cobalt Alloy Implant Debris Induces Inflammation and Bone Loss Primarily through Danger Signaling, Not TLR4 Activation: Implications for DAMP-ening Implant Related Inflammation

Cobalt alloy debris has been implicated as causative in the early failure of some designs of current total joint implants. The ability of implant debris to cause excessive inflammation via danger signaling (NLRP3 inflammasome) vs. pathogen associated pattern recognition receptors (e.g. Toll-like rec...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Samelko, Lauryn, Landgraeber, Stefan, McAllister, Kyron, Jacobs, Joshua, Hallab, Nadim James
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4965114/
https://ncbi.nlm.nih.gov/pubmed/27467577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160141
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