Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential

Tumors exhibit numerous recurrent hemizygous focal deletions that contain no known tumor suppressors and are poorly understood. To investigate whether these regions contribute to tumorigenesis, we searched genetically for genes with cancer-relevant properties within these hemizygous deletions. We id...

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Main Authors: Solimini, Nicole L., Xu, Qikai, Mermel, Craig H., Liang, Anthony C., Schlabach, Michael R., Luo, Ji, Burrows, Anna E., Anselmo, Anthony N., Bredemeyer, Andrea L., Li, Mamie Z., Beroukhim, Rameen, Meyerson, Matthew, Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027969/
https://ncbi.nlm.nih.gov/pubmed/22628553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219580
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