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Thioester Bonds of Thiocoraline Can Be Replaced with NMe-Amide Bridges without Affecting Its DNA-Binding Properties

[Image: see text] In the search for new drug candidates for DNA recognition, affinity and sequence selectivity are two of the most important features. NMe-azathiocoraline, a synthetic antitumor bisintercalator derived from the natural marine product thiocoraline, shows similar potency to the parent...

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Библиографические подробности
Главные авторы: Zamudio-Vázquez, Rubí, Albericio, Fernando, Tulla-Puche, Judit, Fox, Keith R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2013
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027633/
https://ncbi.nlm.nih.gov/pubmed/24900772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400323x
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